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The cDNA of the most frequent mutation of NPM1, mutA, under the control of the pCAG promoter was inserted into the Hprt locus. A stop cassette flanked by loxP sites between the promoter and the cDNA was added, allowing for the conditional expression of the mutant gene upon cre-mediated recombination. (J:202794)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
