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A 940 bp cDNA fragment encoding the signal peptide, extracellular domain, transmembrane domain and part of the intracellular domain, excluding the cytoplasmic kinase domain, of human transforming growth factor, beta receptor II (TGFRB2) was cloned between the mouse alpha A crystallin promoter (nt -366 through +46 of the Cryaa gene) and the small t intron and early region polyadenylation signal of the SV40 virus. The truncated, kinase deficient protein is expressed in the eye lenses of transgenic mice. (J:71882, J:213051)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
