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This transgene consists of a fragment of human FUS 1-359 cDNA including 9 bp of 5'-UTR under the control of the Thy1 promoter. This FUS variant is predominantly cytoplasmic as it lacks the nuclear localization signal, highly aggregate-prone, and lacks a region responsible for RNA recognition and binding. Western blot confirmed expression in neural tissues. (J:203550)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
