The targeting construct inserted into the locus a CAG promoter, loxP site, neomycin resistance/STOP cassette, loxM site, and in an inverted cassette containing loxP and loxM sites, Tbx18 cDNA with a VP16 activator, IRES, Venus reporter sequence and polyadenylation sequence. Cre-mediated recombination is required to achieve expression of the inverted cassette. (J:210076)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count