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Exon 2 was replaced with one in which nucleotide substitutions (AAG to TCG and AAA to TCT) result in the amino acid substitution of serine for lysine at positions 24 and 25 (K24S, K25S). A premature stop codon was introduced into exon 4 preventing the translation of the last 30 amino acids. The predicted product is expected to not be able to interact with heparan sulfate structures while not affecting CXCR4-depedent cell signaling. Cre-mediated recombination removed the floxed neomycin resistance cassette inserted downstream of exon 3. (J:209558)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
