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A targeting vector was constructed to insert loxP sites upstream of exon 43 and downstream of exon 45 of the Piezo2 gene. The vector contained an frt-flanked PGK-neo cassette upstream of the first loxP site. Following homologous recombination in ES cells, the PGK-neo marker and a single loxP site were upstream of exon 43 and a second loxP site was downstream of exon 45. Flp-mediated recombination removed the FRT-flanked neo cassette. (J:211312)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
