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The second exon was replaced with one in which nucleotide substitutions result in the replacement of arginine and lysine at amino acid positions 36 and 37, respectively, by two alanines (RK to AA: R36A, K37A). This mutation in the RK doublet decreases its specific capture by the parvalbumin cells in the visual cortex. Cre-mediated recombination removed a floxed neomycin resistance cassette, leaving a single loxP site downstream of exon 2. (J:185952, J:207121)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
