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A codon-optimized cDNA encoding the salvage enzyme uracil phosphoribosyltransferase (UPRT) from the protozoan parasite Toxoplasma gondii is expressed under the control of the Gt(ROSA)26Sor promoter upon activation by cre recombinase. In cells expressing cre recombinase, and thus T gondii UPRT, 4-thiouracil injected into the mouse is converted to 4-thiouridine that is then incorporated into mRNA; this facilitates isolation and characterization of the transcriptome of a specifc cell population. (J:82809)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
