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Nucleotide substitutions (AGT to GCC) within exon 19 result in the amino acid substitution of alanine for serine at position 743 (S743A). Flp-mediated recombination removed the loxP- and FRT-flanked neomycin resistance cassette inserted downstream of the modified exon 19. This results in a plasmin-inactivating active site mutation. Mice expression normal levels of protein in the plasma but no activity towards the Plm chromogenic substrate, S2251, despite formation of two-chain Plm. (J:210802)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
