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A targeting vector was designed to insert a single loxP site upstream of exon 1 and a frt-flanked neomycin resistance cassette followed by another loxP site downstream of exon 1. Cre-mediated recombination removed the floxed neo cassette and exon 1. Western blot analysis confirmed the absence of protein in the testes. Analysis by RT-qPCR confirmed the absence of transcript in the testes, liver and lung. (J:210656)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
