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The full-length human huntingtin cDNA containing 89 CAG repeats is under the control of the cytomegalovirus promoter and SV40 enhancer. Three lines, A-C, were established. No CAG repeat instability was detected by PCR amplification. Western blot analysis confirmed transgene expression in the brain. Southern blot analysis indicates a copy number of six. (J:50173)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
