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The full-length human huntingtin cDNA containing 48 CAG repeats is under the control of the cytomegalovirus promoter and SV40 enhancer. Three lines, B-D, were established. No CAG repeat instability was detected by PCR amplification. Western blot analysis confirmed transgene expression in the brain, including primary and secondary motor cortices, entorhinal cortex, striatum, hippocampus and cerebellum. Transgene expression in the brain is five times that of endogenous levels. (J:50173)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
