Log In|Sign Up
EN
This transgene contains the unmutated, rearranged immunoglobulin V-D-J and heavy chain enhancer region from the anti-dsDNA producing hybridoma R4A, comprising the S107 V11 heavy chain gene and a Vk1 light chain gene, ligated to a 9.9 kb fragment from all (membrane and secreted) the exons of the Igh-mu constant region (Cu) from BALB/c, which is of the Ighma allotype. Southern blot analysis indicates that the transgene integrated in a single site of the genome. There are 5 copies of the transgene. (J:73871)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
Show/Hide columns
| Phenotypes |
|---|
References Literature
Title
PMID
Journal
Year
IF
