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The transgene contains the entire Ca2+/calmodulin-dependent protein kinase II alpha locus, ~110 kbp 5' flanking region (including the Arsi locus and a portion of the Tcof1 locus) and ~50 kbp 3' flanking region (including the Slc6a7 and Cdx1 loci) from BAC RP23-221H5. The P2X2-YC3.1 fusion gene was inserted immediately upstream of the CaMKIIalpha translation initiation codon in exon 1 via homologous recombination/BAC recombineering. The P2rx2/YC3.1 fusion gene encodes rat P2rx2 fused at its carboxy terminus to the fluorescence resonance energy transfer (FRET)-based optical reporter Yellow Cameleon 3.1 (YC3.1). (J:209943)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
