A loxP-FRT-neo-FRT-exon3/4-loxP cassette was inserted via homologous recombination. Cre-mediated recombination removed the neo cassette and exons 3 and 4. Western analysis confirmed the absence of protein in homozygous mutants. (J:208320)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count