Zinc finger nuclease technology was used to target exon 4. Founder line 6 contains a 2 bp deletion (CTCCAG to CTAG) that introduces a premature stop codon. Flow cytometry confirmed the absence of protein expression on T cells. (J:208927)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count