A floxed neomycin resistance cassette replaced exons 16 through 19 (numbered according to accession NM_146191.3). Cre-mediated recombination removed the neomycin resistance cassette. RT-PCR confirmed the absence of transcript expression in osteoclasts and bone marrow stromal cells. (J:208677)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S/Sv
Targeted
Insertion, Intragenic deletion
--
1
1
2

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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