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Exon 1 of Npr2 was replaced with an nls-lacZ (nuclear localization sequence-lacZ) expression cassette and polyadenylation sequence by homologous recombination in ES cells. The targeting vector also contained a self-excising cre recombinase-neo cassette (cre is expressed from a testis-specific promoter, so the neo is deleted in the male germline). No Npr2 protein was detected in samples from homozygotes. (J:205571)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
