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The full-length human MYC cDNA is under the control of a modified rat probasin promoter that has a sequence composed of 2 repeats of the androgen-responsive region inserted into it (ARR(2)PB). To maximize expression of the transgene, the rabbit beta-globin gene fragment, KCR, which comprises part of exon I, intron I, and exon II, and contains the requisite splice donors and acceptors was added. Western blotting confirmed protein expression in the prostate. Four lines were generated: 32T, 35T, 37T, and 39T. However, the pound symbol (#) is used when line is not specified and/or lines are pooled. (J:205395)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
