Jak2^tm2.1Kpf

Exon 21 was replaced with one in which nucleotide substitutions result in the amino acid substitutions of phenyalanine for tyrosine at positions 1007 and 1008 in the activation loop. Cre-mediated recombination removed a floxed neomycin resistance cassette inserted upstream of exon 20. Western blot analysis confirmed normal protein levels. (J:207710)