Log In|Sign Up
EN
This transgene consists of exon 1 of the human HTT with the expansion of 84 CAG trinucleotide repeats, which encodes 153 amino acids, in the 3' end of the GFP gene, where the stop codon was removed and mutant HTT was ligated in frame, under the control of the human polyubiquitin-C promoter. Western blotting confirmed protein expression in the heart, liver, lung, spleen, kidney, muscle, and brain, with highest levels in the brain. GFP expression was confirmed in the brain. (J:209055)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
Show/Hide columns
| Phenotypes |
|---|
References Literature
Title
PMID
Journal
Year
IF
