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The targeting vector was designed to insert a loxP-flanked PGKneo cassette upstream of exon 2 and loxP site downstream of exon 2. Mutant mice were bred with mice carrying Tg(EIIa-cre)C5379Lmgd to remove exon 2 and the neo cassette. Polymorphisms near the gene demonstrated that the targeted gene is in a genomic region derived from the 129S4/Jae parent of the embryo from which the ES cell line was generated. (J:220524)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
