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This transgene consists of the 1.9 kb human insulin promoter region, rabbit beta-globin intron, human diphtheria toxin receptor (HBEGF) with L148S/P149T mutations, and the polyadenylation signals of rabbit beta-globin and SV40. It was injected into the pronucleus of Prkdcscid eggs. Transgene expression is seen in pancreatic beta cells and administration of diphtheria toxin results in HBEGF expressing cells. (J:204420)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
