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The transgenic construct was derived from that used for Tg(RP23-159N6*)43Bdm, in which the sequence encoding the zinc finger domain of Prdm9 in the C57BL/6J-derived mouse bacterial artificial chromosome (BAC) RP23-159N6 was replaced by the corresponding segment from the Prdm9wm7 allele of strain B10.A(R209)-H2aw9. The present transgene has been further modified by mutation of codons 357-358 from TATGGG to TTTGGT to give rise to a mutant PRDM9 protein in which tyrosine has been replaced by phenylalanine at amino acid position 357 (Y357F). (J:255344)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
