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A loxP site was inserted upstream of the CArG (CC(A/T)6GG) regulatory element in exon 15. An FRT- and loxP-flanked neomycin resistance cassette was inserted downstream of the CArG element. Flp-mediated recombination removed the selection cassette and left the CArG element floxed. This allele targets the smMLCK isoform without affecting full-length Mylk or telokin. Western blot analysis confirmed normal expression of smMLCK isoform. (J:204964)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
