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A BAC (RP24-14N14) containing the entire histidine decarboxylase (Hdc) gene was modified in bacterial cells, replacing the first 47 amino acids of exon 2, intron 1, and exon 1 of Hdc with the cre recombinase coding sequence, SV40 polyadenylation signal and Frt-flanked kanamycin marker. Flp recombination removed the kanamycin cassette. Pronuclear injection of the verified construct produced founder mice. Multiple founders were generated. One founder was verified to have the transgene and produce the expected cre activity in the CNS. (J:194386)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
