Lrp2^b2b2671Clo

This ENU-induced mutation was isolated in a screen at the University of Pittsburgh. The molecular lesion is a T to A substitution at coding nucleotide 6612 in exon 39 of the cDNA (c.6612T>A, NM_001033385). This changes the tyrosine residue to a translation stop at position 2204 of the encoded protein (p.Y2204*). (J:175213) Additional incidental mutations were detected in sequencing for the causative mutation, Lrp2b2b2671Clo, and may be present in stocks carrying this mutation.