Tbc1d32^b2b2596Clo

This ENU-induced mutation was isolated in a screen at the University of Pittsburgh. The molecular lesion is a C to A substitution at coding nucleotide 3096 in exon 27 of the cDNA (c.3096C>A, NM_001033385). This changes the tyrosine residue to a translation stop at position 1032 of the encoded protein (p.Y1032*). (J:175213) Additional incidental mutations were detected in sequencing for the causative mutation, Tbc1d32b2b2596Clo, and may be present in stocks carrying this mutation.