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The transgene was created by targeted insertion of mCherry protein coding sequence into the bacterial artificial chromosome (BAC) MSMG01-526L10. The mCherry sequence was integrated at the stop codon of Tmc1, the only gene in the BAC. The integration site was not investigated. This C-terminal fusion is expressed in the sensory hair cells of the inner ear. Confocal fluorescence images of inner hair cells from transgenic mice at postnatal day 8 (P8) show the transgenic protein localizes predominantly to the tips of the shorter rows of stereocilia. Line 2 carries 7 copies of the transgene. (J:226895)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
