The construct consists of the TRE3G (a third-generation tet-responsive promoter), and EmGFP region, a fusion of Mirlet7a to a modified mir155 terminal loop, an SV40 polyadenylation signal, a 13 kb mouse Vil1 promoter, and a rtTA-M2 sequence. The Mirlet7a/mir155 fusion shRNA is not recognized by LIN28A or LIN28B. (J:202923)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count