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EN
Exon 34 was replaced with a modified one in which nucleotide substitutions (ATC to GCC) result in the amino acid substitution of alanine for isoleucine at position 1169 (I1169A) and a V5 epitope tag. This mutation abolishes the PCNA-binding site. Cre-mediated recombination removed a floxed splice acceptor, IRES and beta-geo cassette inserted upstream of the modified exon 34. (J:202812)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
