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An in frame insertion of a lacZ/neo cassette in exon 1 replaced a 640 bp segment following the endogenous start codon. Quantitative RT-PCR and western blot analysis detected reduced mRNA and protein expression in multiple tissues in heterozygous mice. LacZ expression was detected in the brain, heart and soleus muscle of heterozygous mice. (J:205481)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
