Scn11a^tm1.1Ikth

Exon 16 was replaced with a modified one in which a point mutation (T-to-C) results in the amino acid substitution of leucine with proline at position 799 (p.L799P). This mutation is orthologous to the human mutation p.Leu811Pro observed in patients with loss of pain perception. Cre-mediated recombination removed a floxed neomycin resistance cassette. (J:206848)