A floxed stop cassette followed by a cDNA fragment encoding the mouse Notch3 intracellular domain (amino acids 1668 to 2318), IRES and sequence for YFP were inserted into intron 1. The Notch3 fragment acts as a constitutively active receptor. (J:201985)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count