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A targeting vector was designed to insert a single loxP site 5' of the initiation codon in exon 1 and a loxP-flanked neomycin resistance (neo) cassette followed by a beta-galactosidase (lacZ) sequence downstream of exon 3. Mutant mice were bred to mice carrying Tg(rtetR-tetO-cre)40Mhz. Progeny were selected to retain loxP sites in introns 1 and 3, but an excised neomycin selection cassette. (J:98489, J:101977)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
