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EN
This transgene consists of the platelet-derived growth factor beta promoter, the human APP signal sequence, the amyloid beta containing carboxy-terminal 99 amino acids of APP with the Indiana V717F mutation and the SV40 polyadenylation sequence. The Kozak sequence (GACC) was introduced in front of the ATG codon of the signal sequence to increase translation efficiency. 16 Founder lines were established. This is the highest expressing line. (J:107982)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
