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The C57BL/6 mouse bacterial artificial chromosome (BAC) 148M1 containing the entire Ucp1 gene, and other genes, was modified by inserting sequence encoding cre recombinase, into the translation initiation site into exon 1 of the Ucp1 gene. An FRT site flanked KAN cassette and a loxP site were removed. DNA from the modified BAC clone was used as the source for the transgene, which was microinjected into the pronucleus of FVB fertilized eggs. A founder line was subsequently established. (J:206508, J:214637)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
