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The human STIM1 cDNA encoding the shorter spliced form was cloned into a human ACTA1 promoter (modified with a troponin 1 element to enhance expression in slow fibers) to create a skeletal muscle-specific transgenic strain. Expression is increased approximately 6-fold in the quadriceps, and at uniformly high levels in a broad range of skeletal muscle groups. No expression is observed in the heart. The transgene is integrated on the Y chromosome in this "low expressor" line. (J:101977)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
