A floxed neomycin resistance cassette was inserted upstream of exon 12, and an additional loxP site was inserted downstream of exon 15. Cre-mediated recombination removed the neomycin resistance cassette and left exons 12 through 15 floxed. (J:205446)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count