Log In|Sign Up
EN
A vector containing the bovine rhodopsin promoter (RHO) and cre recombinase with a nuclear localization signal sequence was used for pronuclear injection of C57BL/6 x SJL oocytes. Nine transgenic founders were generated. RT-PCR analysis showed only retina-specific expression with no other positive tissue. The mice were crossed with Rosa26R-lacZ reporter animals to assess cre activity and specificity, with recombination (lacZ staining) detected specifically in rod photoreceptors. (J:205526)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
Show/Hide columns
| Phenotypes |
|---|
References Literature
Title
PMID
Journal
Year
IF
