A loxP site was inserted upstream of exon 1 and a loxP site and FRT flanked selection cassette were inserted downstream of exon 1. The selection cassette was removed leaving exon 1 floxed. (J:201732)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count