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The 186.8 kb C57BL/6 mouse bacterial artificial chromosome (BAC) RP23-446O15 containing the entire Foxp3 gene and other genes, was modified by inserting sequence encoding GFP (Green Fluorescent Protein) followed by a stop codon and the SV40 polyA signal, in frame with the start codon in exon 1 of the Foxp3 gene. None of the other loci on the BAC were modified. The construct is designed to prohibit expression of native or truncated Foxp3 protein. (J:152306)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
