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A construct containing a cassette encoding cre recombinase as well as a neo selection cassette was inserted by recombineering methods into a BAC at the ATG codon of the Lrat locus. The neo was removed by arabinose-induced flippase. Purified BAC DNA was injected into pronuclei of fertilized oocytes. Six founders were positive for the transgene and the line with the strongest cre activity in liver and hemotopoietic stem cells was used for further studies. (J:205330)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
