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EN
TALEN-targeted homologous recombination corrected the T to G nucleotide substitution in the chocolate mutation (Rab38cht) by reconstituting the wild-type sequence encoding glycine at position 19 and thereby eliminating the exogenous SexAI restriction site (cht-GTT to wt-GGT). An identifying neutral nucleotide replacement in codon 18 (G to A) was used as a unique sequence identifier. Silent exchanges within the TALEN binding region remove an endogenous ApaLI site. This allele was identified in a line established from founder Rw2. (J:205086)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
