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This transgene consists of a 135 kb BAC clone, PAC-27 M07, containing the complete 111 kb human SNCA genomic DNA locus with the Parkinson Disease-associated A30P mutation, flanked by 18 kb of 5' and 6 kb of 3' genomic DNA sequence which includes the promoter. Western blot analysis confirmed expression of the human protein in the brain. Line 192 contains a single copy insertion in chromosome 15. (J:201961)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
