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EN
TALENs targeting exon 1 induced a 2 bp deletion at the 52nd base of the coding region. This deletion results in a stop codon and premature truncation after glutamine 17 (p.C18*fs*1). Western blot analysis confirmed the absence of protein expression in mouse embryonic fibroblasts, bone marrow-derived macrophages (BMDMs), peritoneal macrophages, thymus, muscle, colon, intestine, heart, liver, spleen, lung, kidney and brain. (J:204622)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
