A floxed PGK-neomycin selection cassette was inserted into intron 2 and a third loxP site was inserted into intron 3. The selection cassette was then excised from properly targeted clones by cre expression. As a result, exon 3 was flanked by loxP sites. (J:199800)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count