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Point mutations were introduced in exon 41 to express Ala in place of Ser1700 and Thr1704 in the alpha-1 subunit of Cav1.2. The neo cassette was removed by flp mediated recombination. The total number of Cav1.2 channels are reduced by approximately 12% in myocytes from homozygous mice compared with wild-type. (J:203057)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
