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EN
Exon 7 was replaced with one in which nucleotide substitutions result in the amino acid susbtitutions of alanine for cysteine at positions 609 and 612 (C609A, C612A). This mutation disrupts the zinc finger 4-based E3 ligase and ubiquitin binding. Cre-mediated recombnation removed the floxed neomycin resistance cassette inserted downstream of the modified exon 7. (J:203160)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
