A targeting vector containing a FRT site flanked PGK-NEO cassette and a loxP site was inserted into exon 6 of the targeted gene, and another loxP site was inserted upstream of exon 2. Flp-mediated recombination removed the neomycin resistance cassette and left exons 2 through 5 and a portion of exon 6 floxed. (J:203336)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count